It depends I guess. They were used very very often way back in the 90's-late 2000's on monochrome models in games. Someone like @tr1p1ea
would have a much better answer than me. All I can say is that TI-BASIC enhancer libs should probably not use interrupts during TI-OS execution because someone tried to make an interrupt-based grayscale lib in 2004 so that I can redo Reuben Quest: Ev Awakening to run much faster with less flickering, but it was so unstable because interrupts kept conflicting with everything in the TI-BASIC parser or something.
What I hope is that TI won't remove RAM pages or change the CPU or something.